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How Gut Bacteria May Affect the Outcome of Cancer Immunotherapy

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In the ongoing development of cancer immunotherapy, as well as our still developing understanding of the human immune system, there’s always been a bit of massive elephant in the room. The thing about human bodies is that they’re not just human cells, but also consist of trillions of bacteria that mostly live in the intestines. What effect these bacteria have on the immune system’s functioning and from there on immunotherapies was recently investigated by [Tariq A. Najar] et al., with an article published in Nature . The relevant topic here is that of antigenic mimicry , involving microbial antigens that resemble self-antigens. Since these self-antigens are a crucial aspect of both autoimmune diseases and cancer immunotherapy there is considerable room for interaction with their microbial mimics. Correspondingly these mimics can have considerable negative as well as positive implications, ranging from potentially triggering an autoimmune condition to hindering or boosting cancer imm...
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Photographing Rocket Chute Deployment at 10 km

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For those who haven’t been following along, [BPS.space] aka [Joe] is on a journey to launch a home-built rocket past the Kármán line where it will officially reach outer space. But one does not simply launch a rocket to outer space on the first try. The process is long and involves not only building a series of rockets, but designing and building propellant mixtures, solving aerodynamic problems, gaining several model rocket certifications along the way, and a whole host of other steps. He’s also documenting the entire process on video as well, which involves some custom camera work like this rocket selfie camera which will take an image of his rockets at apogee. Like most problems in high-power rocketry, extremely tiny problems have a way of causing catastrophic failure, so every detail needs to be considered and planned for in the final design. For a camera that needs to jettison itself from the rocket at a precise moment after experiencing an incredible amount of forces, this is...
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Autonomous Coin Flipper Flips Expensive Coin

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[Térence Grover] had a very special coin—a  €1,000 commemorative piece only available to Monégasque nationals. If you want to flip one, normally you’d have to go snatch one up from somebody in Monaco— or you could just do it online! Yes, he built an automated online coin flipper to flip this very special piece of coinage. A 12-volt solenoid is fired to flip the coin into the air. It then lands on its 3D-printed tray, where a Raspberry Pi-based computer vision system built with OpenCV and a TFLite model classifies whether the result is heads or tails via a machine learning algorithm. An iris mechanism operated by servo motor then centers the coin on the tray, so it sits back over the solenoid, ready to flip once again. [Térence] was eventually able to refine this simple homemade build to the point that it ran autonomously for a full 50,000 flips on a livestream without issue. The mechanism in this build is not dissimilar to a coin flipper we’ve seen before . We’ve also explored t...
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FLOSS Weekly Episode 868: Remove the Noodles

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This week Jonathan chats with Johannes Millan about Super Productivity and Parallel Code! Those are two very different projects, but both aiming for helping us get our work done. Super Productivity is a scheduling and time tracking suite, while Parallel Code is an almost-IDE for managing and isolating AI coding agents. This episode has something for everybody, so check it out! https://github.com/johannesjo https://super-productivity.com https://parallelcode.app/ Did you know you can watch the live recording of the show right on our YouTube Channel ? Have someone you’d like us to interview? Let us know, or have the guest contact us! Take a look at the schedule here . Direct Download in DRM-free MP3. If you’d rather read along, here’s the transcript for this week’s episode . Places to follow the FLOSS Weekly Podcast: Spotify RSS Theme music: “Newer Wave” Kevin MacLeod (incompetech.com) Licensed under Creative Commons: By Attribution 4.0 License from Blog – Ha...
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Itanium: the Great X86 Replacement that Never Was

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Itanium was once meant to be the next step in computing, to compete with the likes of IBM, Sun and DEC, but also for Intel to have an architecture that couldn’t be taken from it, as the PC was from IBM by its clones. Today, however, Itanium is a relic of the past. [Asianometry] tells us the story of Itanium . By the ’90s, servers were an established market dominated by RISC architectures and Unix-like operating systems. Intel wanted to compete in this market, due in part to worries of losing control over x86. So, when Hewlett Packard came to Intel in late ’93, Intel eventually agreed to collaborate on a new project in EPIC (Explicitly Parallel Instruction Computing). The project initially called PA-WW (later IA-64 and Itanium), was also a radical approach to ILP (Instruction-Level Parallelism). As HP engineers saw RISC architectures potentially hitting performance limits in the future, the idea was a compromise between fully compiler-driven VLIW and the fully hardware-driven super...
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The Electromechanical Computer of the B-52’s Star Tracker

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The Angle Computer of the B-52, opened. (Credit: Ken Shirriff) In the ages before convenient global positioning satellites to query for one’s current location military aircraft required dedicated navigators in order to not get lost. This changed with increasing automation, including the arrival of increasingly more sophisticated electromechanical computers, such as the angle computer in the B-52 bomber’s star tracker that [Ken Shirriff] recently had a poke at . We covered star trackers before , with this devices enabling the automation of celestial navigation. In effect, as long as you have a map of the visible stars and an accurate time source you will never get lost on Earth, or a few kilometers above its surface as the case may be. The B-52’s Angle Computer is part of the Astro Compass, which is the star tracker device that locks onto a star and outputs a heading that’s accurate to a tenth of a degree, while also allowing for position to be calculated from it. Inside the devic...
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Analog Circuitry Lets You Blow This LED Out

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LED candles are neat, but they’re very suboptimal for wish-making: you can’t blow them out. Unless you take the circuit from [Andrea Console]’s latest project that lets you do just that, using only analog electronics — no microcontroller in sight. He’s using the known temperature-voltage behaviour of the LED for control here– sort of like the project we saw in last year’s Component Abuse Challenge that let you illuminate the LED with a butane lighter . Here it’s a bit less dramatic, relying only on the small cooling effect your breath has on the LED. There are two parts to the circuit, really– a latching section to turn the thing on from a single button press, and breath-detecting section. The breath-detecting section relies on an op-amp acting as a comparator, comparing the voltage across the LED’s current-limiting resistor, and a reference stored in a 100 µF capacitor. Blowing on the candle spikes the voltage on the LED, and thus the current-limiting resistor too fast for the capa...
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