Kritik sah

Seizure in zebrafish larva imaged using AO setup. (Credit: Bingxi Liu et al ., Biomedical Optics Express, 2026) Key to understanding something like epilepsy is to be able to record highly transient events in biological tissues. Generally this is done using light sheet microscopy, which provides effectively a 2D ‘slice’ of the tissue in question, but to observe a brief event in a larger biological system you need to be able to rapidly change the layer and focus between the virtual layers. This is what [Bingxi Liu] et al. al did using adaptive optics with an electrically tunable lens (ETL) in order to capture seizures in the brain of zebrafishes . Their system can capture a volume of 499 × 499 × 150  μ m 3 at 4 volumes per second, which is large enough to fit optically transparent zebrafish larva into. The optical setup is shown in the above image, with the design based on the OpenSPIM platform for selective plane illumination microscopy. Here the 488 nm laser provides th...

The standard computer mouse is a perfectly useful peripheral  if your hands work.  If you’ve got some trouble in that area, you might appreciate an alternative input solution. To that end, [Varun Adinath Patil] created a neat hands-free solution for moving a cursor around a screen. The build is based on the Neuro PlayGround Lite, a board built for physiological signal acquisition in the Feather form factor. It’s hooked up to an IMU sensor—both a MPU6050 or BMI270 work—which tracks head movements to allow the cursor to be panned around the screen. Other biological signals are then used to activate other standard mouse functions. Clenching the jaw fires off a left click, while a triple blink fires a right click. Clicking and dragging is achieved by a double-blink. The jaw muscles are sensed via EMG signals picked up with gel electrodes on the skin, while the blinks are detected via EOG signals via the same contact points. Commercial solutions in this realm exist, but it...

Community-led open source project hosting site Codeberg has formally announced that projects whose code is largely or fully machine-generated through LLMs and other ‘AI’ tools will no longer be welcome. This follows on the heels of a similar ban on cryptocurrency-related projects. The community vote was on two issues, the first being the notion that scraping of project code for the use in LLMs should be forbidden, which was a motion that easily passed. The second motion was on disallowing projects whose code was substantially generated by LLMs like Claude, OpenAI Codex, and similar. This motion passed with 358 in favor versus 144 against. In the earlier linked blog post the reasoning behind especially this second issue is expanded upon, covering not only ‘license whitewashing’, but also the direct and indirect hardware costs, with the expanding ‘AI’ datacenter hyperscaling having massively increased hardware costs for Codeberg over the past years, ...

[Myth Made] has a goal to get into writing. However, she likes to do things the  aesthetic way, rather than the easy way. Thus, she has eschewed simple word processing on a conventional computer, instead choosing to build a remarkably attractive writing deck styled after a classic typewriter. The keycap marking technique is worth watching the video for on its own. The build began with a mechanical keyboard with a compact layout. The square keycaps were swapped out for custom 3D printed versions that were rounded to suit the desired look. [Myth Made] used a neat technique where the caps were colored in with a paint marker and then ran through a laser engraver to bond the paint to the surface to make all the key markings. With the input side sorted, the rest of the build could progress. The typewriter shell was printed in multiple parts, and then welded together with acetone. This was then covered with an ABS-acetone solution that helped remove some of the surface artifacts, before p...

When an individual is born with genetic defects, there are a few ways to deal with the impact of the faulty genes. The most extreme solution is direct DNA editing to repair the mutation, while the treatment of symptoms with medication is the least invasive, though this comes with its own set of disadvantages. Antisense therapy keeps a middle ground here, by targeting the messenger RNA (mRNA) that forms the bridge between DNA and the translation into a functional protein by the ribosome. In a recent study by [Olivia Kim-McManus] et al. antisense therapy with an allele-specific feature was demonstrated in two individuals with  SCN2A mutations. These mutations had resulted in severe epilepsy and developmental disorders, due to how instrumental this gene is for normal functioning of the human central nervous system (CNS) where it regulates the initiation of action potentials. Although SCN2A mutations are rarely inherited, for the approximately 1 in 80,000 affected the consequences can...

We enjoyed [Beej’s] trip down memory lane looking at a BASIC game , The Wizard’s Castle, written for the Exidy Sorcerer. It appeared in a 1980 magazine that included the title graphic above. It reminded us how, back in those days, we did things with BASIC that you shouldn’t be able to do and it often looks, today, rather cryptic. In particular, even if you know modern BASIC, these few lines might give you a pause: 10 REM"_(C2SLFF4 40 POKE 260,218: POKE 261,1: T = USR(0): T = PEEK(-2049) 80 Q = RND(-(2*T+1)) Line 10 is a comment, but a strange one. Certainly that doesn’t matter, right? Actually, it is a key part of the action. On line 40, you can see some pokes to write directly to memory and a peek to read some memory value back. The USR function calls some machine language program. You may realize the whole thing is to get some value T to seed the random number generator in line 80. This leads to a few obvious questions. First, how does USR know what to call...